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Abstract #0435

Water-Only Look-Locker Inversion recovery (WOLLI) T1 mapping

Liam D. Garrison1, Christina Levick1,2, Michael Pavlides1,2, Tom Marjot3, Ferenc Mozes1, Leanne Hodson3, Stefan Neubauer1, Matthew Robson1, and Christopher T. Rodgers1

1OCMR, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 3Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Radcliffe Department of Medicine, University of Oxford, United Kingdom

We propose a new “Water-Only Look-Locker Inversion recovery” (WOLLI) sequence, based on MOLLI, that enables water-selective T1-mapping in an 8hb breath-hold at 3T. WOLLI uses a hypergeometric (HG) inversion pulse to selectively invert water with negligible effect on fat. To separate the steady-state fat and water signals, WOLLI adds one or more fat-inversions starting from the plateau of the water T1* recovery. WOLLI uses an extended Deichmann-Haase formula to correct for readout-induced saturation. We validated this approach by simulations, scans in a phantom containing 19 fat/water mixtures, and liver scans in 12 subjects (volunteers and liver disease patients).

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