Abstract #0436

Region-of-interest size of hepatic 2D MR elastography decreases with increasing R2* for gradient-echo but not spin-echo techniques

Cheng William Hong¹, Adrija Mamidipalli¹, Ethan Z Sy¹, Jonathan C Hooker¹, Calvin Andrew Tran¹, Tanya Wolfson², Soudabeh Fazeli Dehkordy¹, Scott B Reeder³, Rohit Loomba⁴, and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Computational and Applied Statistics Laboratory, University of California, San Diego, San Diego, CA, United States, ³Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States, ⁴NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA, United States

MR elastography (MRE) is an emerging technique for the non-invasive assessment of hepatic stiffness and fibrosis, and can be based on gradient-echo (GRE) or spin-echo (SE) acquisition. This study demonstrates that 2D-SE provides significantly larger reliable-wave-quality regions-of-interest (ROIs) than 2D-GRE at 3T. Additionally, 2D-GRE ROI sizes are negatively correlated with hepatic R2*, while 2D-SE ROI sizes are not associated with R2*. This suggests that 2D-SE may be the preferred MRE sequence at 3T and in patients with known iron overload.

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