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Abstract #0437

Estimating Liver Function in Chronic Liver Disease Patients Using DCE-MRI and Whole-Body Pharmacokinetic Modeling

Markus Karlsson1,2, Mikael F Forsgren1,2, Olof Dahlqvist-Leinhard1,2, Nils Dahlström1,2, Bengt Norén2, Mattias Ekstedt1, Stergios Kechagias1, Gunnar Cedersund3, and Peter Lundberg1,2

1Department of Health and Medicine, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualisation, Linköping University, Linköping, Sweden, 3Department of Biomedical Engineering, Linköping University, Linköping, Sweden

Dynamic contrast enhanced MRI with Gd-EOB-DTPA is a promising method for investigating liver function. However, many of the proposed procedures relies on such a high temporal resolution, and low spatial resolution, that the images are rendered unsuitable for radiographic reading. Here we have tested and validated a recently developed procedure using a whole-body pharmacokinetic model in a cohort of patients with chronic liver disease. Moreover we also show that the approach can separate advanced from mild fibrosis.

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