Abstract #0437

Estimating Liver Function in Chronic Liver Disease Patients Using DCE-MRI and Whole-Body Pharmacokinetic Modeling

Markus Karlsson^1,2, Mikael F Forsgren^1,2, Olof Dahlqvist-Leinhard^1,2, Nils Dahlström^1,2, Bengt Norén², Mattias Ekstedt¹, Stergios Kechagias¹, Gunnar Cedersund³, and Peter Lundberg^1,2

¹Department of Health and Medicine, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualisation, Linköping University, Linköping, Sweden, ³Department of Biomedical Engineering, Linköping University, Linköping, Sweden

Dynamic contrast enhanced MRI with Gd-EOB-DTPA is a promising method for investigating liver function. However, many of the proposed procedures relies on such a high temporal resolution, and low spatial resolution, that the images are rendered unsuitable for radiographic reading. Here we have tested and validated a recently developed procedure using a whole-body pharmacokinetic model in a cohort of patients with chronic liver disease. Moreover we also show that the approach can separate advanced from mild fibrosis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.