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Abstract #0462

Parallel processes of neuro-vascular and neuro-cellular coupling

Wen-Ju Pan1, Jacob Billings1, Maysam Nezafati1, Waqas Majeed1, and Shella Keilholz1

1Emory University/Georgia Institute of Technology, Atlanta, GA, United States

Neural activity leads to cellular swelling along with the hemodynamic response from the vasculature. The latter process is the basis for the BOLD signal detected with fMRI; the former may underlie the changes observed with diffusion-weighted fMRI. Optical intrinsic signals can detect neuro-vascular activity (typically observed in in vivo studies of reflectance) and neuro-cellular swelling (observed mostly by transmittance in brain slices). We designed a novel miniature probe for in vivo transmittance studies in the rat brain and examined neuro-cellular coupling and neuro-vascular coupling in vivo to better understand the basis of the MRI techniques.

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