Abstract #0463

Functional response of corpus callosum to electrical stimulation of S1 cortex in mice

Tsen-Hsuan (Abby) Lin¹, Willaim M Spees^1,2, Michael Wallendorf³, Yen-Yu Ian Shih⁴, Anne H Cross^2,5, and Sheng-Kwei Song^1,2,6

¹Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²The Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States, ³Biostatistics, Washington University School of Medicine, St. Louis, United States, ⁴Neurology, The University of North Carolina in Chapel Hill, NC, United States, ⁵Neurology, Washington University School of Medicine, St. Louis, MO, United States, ⁶Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States

The corpus callosum (CC) is the major pathway for interhemispheric communication and a primary target of white-matter neurodegenerative diseases. Diffusion MRI is widely used to assess white-matter structural alternations in diseases. In addition to morphological changes, we previously demonstrated the feasibility to assess white matter function using diffusion MRI. We observed a 27% perpendicular apparent diffusion coefficient (ADC_⊥) decrease in normal mouse optic nerve during visual stimulation. In the current study, we implanted MR-compatible tungsten wires at primary somatosensory cortex and observed 15 – 21% ADC_⊥ decrease in CC, suggesting diffusion MRI can be applied to study function at this site.

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