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Abstract #0463

Functional response of corpus callosum to electrical stimulation of S1 cortex in mice

Tsen-Hsuan (Abby) Lin1, Willaim M Spees1,2, Michael Wallendorf3, Yen-Yu Ian Shih4, Anne H Cross2,5, and Sheng-Kwei Song1,2,6

1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2The Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States, 3Biostatistics, Washington University School of Medicine, St. Louis, United States, 4Neurology, The University of North Carolina in Chapel Hill, NC, United States, 5Neurology, Washington University School of Medicine, St. Louis, MO, United States, 6Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States

The corpus callosum (CC) is the major pathway for interhemispheric communication and a primary target of white-matter neurodegenerative diseases. Diffusion MRI is widely used to assess white-matter structural alternations in diseases. In addition to morphological changes, we previously demonstrated the feasibility to assess white matter function using diffusion MRI. We observed a 27% perpendicular apparent diffusion coefficient (ADC) decrease in normal mouse optic nerve during visual stimulation. In the current study, we implanted MR-compatible tungsten wires at primary somatosensory cortex and observed 15 – 21% ADC decrease in CC, suggesting diffusion MRI can be applied to study function at this site.

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