Abstract #0469

More Than Simply Iron: How the Mesoscopic and Cellular Distribution of Iron Impacts the MR Contrast

Evgeniya P. Kirilina^1,2, Katja Reimann³, Isabel Weigelt³, Thomas Arendt³, Andreas Deistung^4,5, Jürgen R. Reichenbach⁴, Steffen Jankuhn⁶, Larissa Müller⁷, Norbert Jakubowski⁷, Markus Morawski³, and Nikolaus Weiskopf¹

¹Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Center for Cognitive Neuroscience Berlin, Free University Berlin, Berlin, Germany, ³Paul-Flechsig-Institute for Brain Research, Leipzig, Germany, ⁴Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany, ⁵Section of Experimental Neurology, Department of Neurology, Essen University Hospital, ⁶Department of Solid State Physics, Faculty of Physics and Earth Sciences Leipzig University, Leipzig, ⁷Bundesanstalt für Materialforschung und –prüfung BAM, Berlin, Germany

Iron is an important source of MRI contrast in the brain. Herein, we investigated the influence of the cellular and subcellular iron distribution on the iron-induced MR contrast. Quantitative MRI on post mortem brain samples was combined with quantitative iron mapping and numerical simulations of local field distributions. We show that iron is heterogeneously distributed in both grey and white matter as well as in subcortical nuclei and different scales of heterogeneity play a role for MR contrast in these regions. Our results provide an important step towards quantitative understanding of iron induced MR-contrast and its microstructural underpinnings.

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