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Abstract #0469

More Than Simply Iron: How the Mesoscopic and Cellular Distribution of Iron Impacts the MR Contrast

Evgeniya P. Kirilina1,2, Katja Reimann3, Isabel Weigelt3, Thomas Arendt3, Andreas Deistung4,5, Jürgen R. Reichenbach4, Steffen Jankuhn6, Larissa Müller7, Norbert Jakubowski7, Markus Morawski3, and Nikolaus Weiskopf1

1Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Center for Cognitive Neuroscience Berlin, Free University Berlin, Berlin, Germany, 3Paul-Flechsig-Institute for Brain Research, Leipzig, Germany, 4Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany, 5Section of Experimental Neurology, Department of Neurology, Essen University Hospital, 6Department of Solid State Physics, Faculty of Physics and Earth Sciences Leipzig University, Leipzig, 7Bundesanstalt für Materialforschung und –prüfung BAM, Berlin, Germany

Iron is an important source of MRI contrast in the brain. Herein, we investigated the influence of the cellular and subcellular iron distribution on the iron-induced MR contrast. Quantitative MRI on post mortem brain samples was combined with quantitative iron mapping and numerical simulations of local field distributions. We show that iron is heterogeneously distributed in both grey and white matter as well as in subcortical nuclei and different scales of heterogeneity play a role for MR contrast in these regions. Our results provide an important step towards quantitative understanding of iron induced MR-contrast and its microstructural underpinnings.

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