Abstract #0468

Frequency difference mapping as a marker of microstructural integrity of white matter in multiple sclerosis at 7T

Matthew Cronin¹, Nicholas Geades², Olivier Mougin², Kingkarn Aphiwatthanasumet², Nikos Evangelou², Penny Gowland², and Richard Bowtell²

¹University of California, Berkeley, CA, United States, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Frequency difference maps derived from GRE phase data have been shown to generate orientation-dependent contrast in white matter tracts in the brain due to signal compartmentalization in myelinated nerve fibers. Here, we investigate the use of frequency difference mapping (FDM) as a marker of white matter integrity; comparing FDM with PSIR; T2*-weighted magnitude; and quantitative susceptibility mapping (QSM) images of focal white matter lesions in patients with multiple sclerosis. FDM shows clear contrast between these lesions and the surrounding white matter, suggesting that it has potential as a means of quantitatively identifying changes in white matter integrity in vivo.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.