Abstract #0471

Combining inhomogenous Magnetization Transfer (ihMT) with multi-point Dixon (mDixon) for myelin imaging with efficient fat suppression

Ece Ercan¹, Ivan E Dimitrov^2,3, Gopal Varma⁴, Xinzeng Wang¹, Marco Pinho^1,2, Ananth J Madhuranthakam^1,2, Robert E Lenkinski^1,2, and Elena Vinogradov^1,2

¹Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Philips Healthcare, Gainesville, FL, United States, ⁴Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) imaging is a novel enhanced magnetization transfer technique which has recently been applied in human brain and spinal cord. Spinal cord applications of ihMT can especially benefit from a robust fat suppression to help with reducing of the strong fat signal from the large voxel size used by this method. Here we introduce a pulsed ihMT-prepared 3D SPGR sequence with multi-echo Dixon acquisition for a robust fat suppression of the ihMT images. The ihMT multi-echo Dixon method is shown to provide an excellent fat and water separation without a compromise of the observable ihMT effect.

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