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Abstract #0472

Anisotropy of inhomogeneous Magnetization Transfer (ihMT) in White Matter

Olivier M. Girard1, Valentin H. Prevost1, Samira Mchinda1, Gopal Varma2, David C. Alsop2, and Guillaume Duhamel1

1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) is a new endogenous contrast mechanism that has been proposed for imaging myelinated tissues. The dipolar interaction underlying the ihMT effect is intrinsically anisotropic, exhibiting the well-known (3cos²θ -1) angle dependency. Here we report experimental evidence of the anisotropy of ihMT in white matter and we derive a realistic theoretical model combining the angular dependency of the myelin lineshape and dipolar-order RF saturation theory.

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