Abstract #0474

Towards a non-contrast assessment of blood-brain-barrier permeability

Zixuan Lin¹, Yang Li², Pan Su², Jay J. Pillai², Matthias van Osch³, and Hanzhang Lu²

¹Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ³C.J. Gorter Center for high field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands

Blood-brain-barrier (BBB) permeability has been shown to be disrupted in many diseases. Current study proposes a non-invasive method to measure the extraction fraction and BBB permeability of water. Studies were performed to provide proof-of-principle and a new sequence was developed to improve efficiency. These methods provided consistent results with previous literature. CO₂ effect on permeability was explored and increased measurement sensitivity was demonstrated.

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