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Abstract #0474

Towards a non-contrast assessment of blood-brain-barrier permeability

Zixuan Lin1, Yang Li2, Pan Su2, Jay J. Pillai2, Matthias van Osch3, and Hanzhang Lu2

1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 3C.J. Gorter Center for high field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands

Blood-brain-barrier (BBB) permeability has been shown to be disrupted in many diseases. Current study proposes a non-invasive method to measure the extraction fraction and BBB permeability of water. Studies were performed to provide proof-of-principle and a new sequence was developed to improve efficiency. These methods provided consistent results with previous literature. CO2 effect on permeability was explored and increased measurement sensitivity was demonstrated.

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