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Abstract #0475

Non-invasive Assessment of Vascular Water Permeability in the Mouse Brain using multi-TE ASL

Yolanda Ohene 1, Ian F Harrison 1, Payam Nahavandi 1, Ozama Ismail 1, David Thomas 2, Mark Lythgoe 1, and Jack Wells 1

1UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, 2Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, London, United Kingdom

We apply a multi-TE ASL technique in the mouse brain, to separate intravascular and extravascular components of the ASL signal, as a non-invasive assessment of vascular permeability. Methodological development enabled the technique to reliably capture ASL signal compartmentation in the mouse brain, despite inherently low SNR. We report a significant decrease in intravascular fraction of the ASL signal from 0.66 (± 0.17) to 0.35 (± 0.10) as inflow time increases from 1000ms to 1500ms. This technique can be applied to transgenic mouse models of neurodegeneration, and a kinetic model can extract vascular permeability parameters from the ASL signal distribution.

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