We apply a multi-TE ASL technique in the mouse brain, to separate intravascular and extravascular components of the ASL signal, as a non-invasive assessment of vascular permeability. Methodological development enabled the technique to reliably capture ASL signal compartmentation in the mouse brain, despite inherently low SNR. We report a significant decrease in intravascular fraction of the ASL signal from 0.66 (± 0.17) to 0.35 (± 0.10) as inflow time increases from 1000ms to 1500ms. This technique can be applied to transgenic mouse models of neurodegeneration, and a kinetic model can extract vascular permeability parameters from the ASL signal distribution.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords