Abstract #0492

MRS measurements of [2-13C] glycine conversion to glutathione in the liver: A new method of measuring hepatic oxidative stress defences in vivo

Stephen Bawden^1,2, Bernard Lanz², Mehri Kaviani², Peter Morris², Penny Gowland², Peter Thelwall^3,4, and Guruprasad P Aithal¹

¹NIHR Nottingham Digestive Diseases Unit, Nottingham University Hospitals, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Center, Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ³Newcastle Magnetic Resonance Center, Newcastle University, ⁴Institute of Cellular Medicine, Newcastle University

With rising incidents of fatty liver disease and metabolic disorder there is a need for biomarkers that can assess progression to steatohepatitis and other forms of liver damage. Oxidative stress in the mitochondria may play a central role in disease progression, with glutathione acting as the main antioxidant. In this study we developed a method previously suggested to monitor hepatic glutathione production in vivo by administering oral [2-13C] labelled glycine and using ¹³C MRS to measure conversion to glutathione. Following optimization, we tested variability in 8 healthy volunteers over two visits.

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