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Abstract #0492

MRS measurements of [2-13C] glycine conversion to glutathione in the liver: A new method of measuring hepatic oxidative stress defences in vivo

Stephen Bawden1,2, Bernard Lanz2, Mehri Kaviani2, Peter Morris2, Penny Gowland2, Peter Thelwall3,4, and Guruprasad P Aithal1

1NIHR Nottingham Digestive Diseases Unit, Nottingham University Hospitals, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Center, Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 3Newcastle Magnetic Resonance Center, Newcastle University, 4Institute of Cellular Medicine, Newcastle University

With rising incidents of fatty liver disease and metabolic disorder there is a need for biomarkers that can assess progression to steatohepatitis and other forms of liver damage. Oxidative stress in the mitochondria may play a central role in disease progression, with glutathione acting as the main antioxidant. In this study we developed a method previously suggested to monitor hepatic glutathione production in vivo by administering oral [2-13C] labelled glycine and using 13C MRS to measure conversion to glutathione. Following optimization, we tested variability in 8 healthy volunteers over two visits.

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