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Abstract #0491

Detection of Carbonic Anhydrase Activity in Human Brain in Vivo

Shizhe Li1, Li An1, Christopher Johnson1, Maria Ferraris Araneta1, and Jun Shen1

1National Institutes of Health, Bethesda, MD, United States

This study demonstrates the feasibility of detecting carbonic anhydrase activity in the human brain. A very large magnetization transfer effect on the bicarbonate signal was measured in healthy human subjects using 13C MRS upon saturation of carbon dioxide. Despite the large variations in blood glucose response to oral administration of 13C-labeled glucose the magnetization transfer effect was measured with high precision.

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