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Abstract #0490

Coupling of the glutamate-glutamine cycle rate with both glial and neuronal oxidative metabolism in the visual cortex of the Tupaia belangeri

Sarah Sonnay1, Jordan Poirot2, Nathalie Just3, Anne-Catherine Clerc1, Rolf Gruetter1,4,5, Gregor Rainer2, and João M.N. Duarte1

1Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fedérale de Lausanne (EPFL), Lausanne, Switzerland, 2Department of Medicine, Visual Cognition Laboratory, University of Fribourg, Fribourg, Switzerland, 3University Hospital Münster, Münster, Germany, 4Department of Radiology, University de Lausanne, Lausanne, Switzerland, 5Department of Radiology, University de Geneva, Geneva, Switzerland

Cerebral function relies on cooperative interaction between neuronal and glial cells. While neuronal oxidative metabolism has been shown to be coupled to the glutamate-glutamine cycle that represents glutamatergic neurotransmission, it remains unclear whether similar coupling occurs for glial oxidative metabolism. We investigated cortical metabolism in vivo using 13C magnetic resonance spectroscopy (MRS) along with infusion of [1,6-13C]glucose during continuous stimulation of the tree shrew visual cortex (V1). Data indicate that both neuronal and glial oxidative metabolism scale with the glutamate-glutamine cycle.

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