Abstract #0489

Multi-echo chemical shift encoding (MECSE) for sensitive fluorine-19 MRI of complex spectra

Ruud B van Heeswijk¹, Roberto Colotti¹, Emeline Darçot¹, Jean Delacoste¹, Maxime Pellegrin², Davide Piccini^1,3, and Diego Hernando^4,5

¹Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ²Angiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Now that several clinical trials are underway, sensitive fluorine-19 MRI of biocompatible perfluorocarbons with complex MR spectra, such as perfluorooctyl bromide (PFOB), is seeing increased interest. We here therefore propose a novel multi-echo chemical shift encoding (MECSE) technique that accounts for all resonances in k-space and reconstructs a high-sensitivity image free of chemical-shift-displacement artifacts. MECSE was developed and characterized in a phantom study, compared to established techniques for imaging compounds with complex spectra, and preliminarily demonstrated in vivo.

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