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Abstract #0488

DIrect EStimation of 17O MR ImageS (DIESIS) for CMRO2 Quantification in the Human Brain with Partial Volume Correction

Dmitry Kurzhunov1, Robert Borowiak1,2,3, Marco Reisert1, Axel Joachim Krafft1, and Michael Bock1

1Dept. of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, 2German Cancer Consortium (DKTK), Heidelberg, Germany, 3German Cancer Research Center (DKFZ), Heidelberg, Germany

Direct 17O-MRI enables quantification of cerebral metabolic rate of oxygen consumption (CMRO2). The low MR sensitivity of the 17O nucleus prevents pixel-wise CMRO2 quantification and the fast T2*≈2ms decay leads to partial volume artifacts. In this work the DIESIS method is proposed, which performs a direct least squares estimation of the 17O‑MR signal in image regions (parcels) obtained from coregistered 1H data. CMRO2 values of 1.38-1.87µmol/gtissue/min and 0.51-0.77µmol/gtissue/min were found with DIESIS in gray and white matter consistent with rates from 15O-PET studies. With DIESIS, CMRO2 maps of high resolution can be reconstructed and partial volume artifacts can be reduced.

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