Abstract #0487

Using Hyperpolarized 129Xe MRI to Detect Impaired Cerebral Perfusion in Human Brain with Alzheimer’s Disease

Tao Li¹, Francis T. Hane^1,2, Jane M. Lawrence-Dewar², Ayman Hassan³, Karl Granberg³, Raiili M. Pellizzari¹, Jennifer A. Plata², and Mitchell S. Albert^1,2,4

¹Department of Chemistry, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada, ⁴Northern Ontario School of Medicine, Thunder Bay, ON, Canada

In this work, we present the first hyperpolarized ¹²⁹Xe human brain MR spectra and human brain MR images from participants with Alzheimer’s Disease. We found a marked difference in the wash-out of dissolved phase xenon from the brain between the two groups, likely resulting from impaired cerebral blood flow in the Alzheimer’s Disease participants. By exploring this difference, we demonstrate the feasibility and sensitivity of hyperpolarized ¹²⁹Xe MRI in detecting changes in cerebral perfusion and evaluating this important physiological characteristic during an early stage of mild to moderate Alzheimer’s Disease.

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