Phosphorus-containing biomolecules play a crucial role in the energy metabolism of the human body. Compared to hydrogen, the in vivo phosphorus MR signal is four orders of magnitude lower. In this study, a conventional gridding reconstruction applied on the phosphocreatine signal of the human calf was compared to a constraint iterative approach, which uses prior knowledge from hydrogen MRI data. For both reconstructions, different acquisition times were tested and phosphocreatine concentrations in the gastrocnemius and soleus muscles were estimated.
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