Abstract #0496

LONG TERM EFFECTS OF PULSED FOCUSED ULTRASOUND AND MICROBUBBLES DETECTED BY MULTIVARIATE IMAGING MODALITIES

Zsofia I Kovacs¹, Tsang-Wei Tu¹, Georgios Z Papadakis^1,2, William C Reid², Dima A Hammoud², and Joseph A Frank^1,3

¹Frank Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States, ²Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ³National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States

Blood brain barrier (BBB) opening by MR-guided pulsed Focused Ultrasound (pFUS) and microbubbles (MB) is a non-invasive treatment of various central nervous system diseases. However, the potential adverse effects of repeated pFUS+MB exposure have not been thoroughly elucidated and may limit clinical translation. To date MRI scans of repeated BBB opening by pFUS+MB have been achieved without hemorrhage, edema and behavioral changes in non-human primates (Arvanitis, et al. 2015; Downs, et al. 2015). By incorporating detailed multivariate imaging modalities we characterized the long term effects of single or repeated pFUS+MB in the rat brain.

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