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Abstract #0501

Multimodal Imaging of Vascularity and Drug Delivery in GBM Patients Treated with Anti-angiogenesis Inhibitor

Yi-Fen Yen1, Jayashree Kalpathy-Cramer1, Ciprian Catana1, Xiao Da2, Yangming Ou1, Andrew L. Beers1, Jacob Hooker1, Bruce Rosen1, Tracy Batchelor3, and Elizabeth R. Gerstner3

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Functional Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, United States, 3Department of Neuro-oncology, Massachusetts General Hospital, Boston, MA, United States

Anti-angiogenic agents can decrease vessel permeability and perfusion, raising concerns that these agents may also decrease blood brain barrier penetration of concomitantly administered chemotherapy. Using MR-PET multimodal imaging, we found radiolabeled temozolomide correlated with permeability and perfusion in patients with recurrent GBM treated with bevacizumab. MR assessment of vascularity may be a surrogate marker for concomitant drug delivery.

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