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Abstract #0502

Haemodynamic and metabolic MR biomarkers of disease progression in an animal model of relapsing-remitting multiple sclerosis

Mohamed Tachrount1, Andrew Davies1, Flavia Rosianu1, Roshni Desai1, David Thomas1, Kenneth Smith1, and Xavier Golay1

1Institute of Neurology, UCL, London, United Kingdom

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disorder of unknown cause affecting the central nervous system. We have assessed haemodynamic and metabolic alterations within spinal cord during disease progression in an animal model (experimental autoimmune encephalomyelitis (EAE) by combining both arterial spin labelling (ASL) and MR Spectroscopy. We demonstrate for the first time that the neurological deficits are strongly correlated with impaired blood flow and reveal both reversible and irreversible simultaneous metabolic alterations.

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