Abstract #0503

Multimodal MR investigation of brain and behavioral changes in patients with HIV-infections

Michael Albert Thomas¹, Rajakumar Nagarajan², Eric S Daar³, Santosh K Yadav⁴, Charles H Hinkin⁵, Manoj K Sarma⁶, Zohaib Iqbal¹, Sathya Arumugam¹, Mario Guerrero ³, Mohammad Haris⁴, and Ebrahim Haroon⁷

¹Radiological Sciences, UCLA Geffen School of Medicne, los angeles, CA, United States, ²Radiological Science, UCLA Geffen School of Medicine, los angeles, CA, United States, ³Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States, ⁴Research Branch, Sidra Medical and Research center, Doha, Qatar, ⁵Psychiatry, UCLA Geffen School of Medicine, Los Angeles, CA, United States, ⁶Radiological Sciences, UCLA Geffen School of Medicine, Los Angeles, CA, ⁷Psychiatry, Emory University, Atlanta, GA, United States

Regional brain volumes and cortical thickness using 3D T1-weighted MP-RAGE and neurometabolites quantitated using 5D EP-JRESI MRSI were obtained from a group of HIV+ (n=16) and HIV-subjects (n=15). Compared to HIV- subjects, following findings were observed in HIV+: i) decreases in the volume of right thalamus, mid anterior corpus callosal region and cortex (right, left, combined), and ii) decreases in cortical thickness of superior parietal and inferior temporal regions. The cortical thickness and volumetric changes were predicted by (increased choline, decreased NAA and Glx). Right basal ganglia glutamate/glutamine ratios and HIV+ status together significantly predicted psychomotor slowing during neurocognitive testing.

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