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Abstract #0503

Multimodal MR investigation of brain and behavioral changes in patients with HIV-infections

Michael Albert Thomas1, Rajakumar Nagarajan2, Eric S Daar3, Santosh K Yadav4, Charles H Hinkin5, Manoj K Sarma6, Zohaib Iqbal1, Sathya Arumugam1, Mario Guerrero 3, Mohammad Haris4, and Ebrahim Haroon7

1Radiological Sciences, UCLA Geffen School of Medicne, los angeles, CA, United States, 2Radiological Science, UCLA Geffen School of Medicine, los angeles, CA, United States, 3Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States, 4Research Branch, Sidra Medical and Research center, Doha, Qatar, 5Psychiatry, UCLA Geffen School of Medicine, Los Angeles, CA, United States, 6Radiological Sciences, UCLA Geffen School of Medicine, Los Angeles, CA, 7Psychiatry, Emory University, Atlanta, GA, United States

Regional brain volumes and cortical thickness using 3D T1-weighted MP-RAGE and neurometabolites quantitated using 5D EP-JRESI MRSI were obtained from a group of HIV+ (n=16) and HIV-subjects (n=15). Compared to HIV- subjects, following findings were observed in HIV+: i) decreases in the volume of right thalamus, mid anterior corpus callosal region and cortex (right, left, combined), and ii) decreases in cortical thickness of superior parietal and inferior temporal regions. The cortical thickness and volumetric changes were predicted by (increased choline, decreased NAA and Glx). Right basal ganglia glutamate/glutamine ratios and HIV+ status together significantly predicted psychomotor slowing during neurocognitive testing.

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