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Abstract #0527

Free-breathing 3D whole-heart stress myocardial perfusion using compressed sensing

Merlin J Fair1,2, Eliana Reyes1, Peter D Gatehouse1,2, Ganesh Adluru3, Jason Mendes3, Ricardo Wage1, Edward VR DiBella3, and David N Firmin1,2

1CBRU, Royal Brompton Hospital, London, United Kingdom, 2NHLI, Imperial College London, London, United Kingdom, 3UCAIR, University of Utah, UT, United States

A consistent, reliable, 3D myocardial first-pass perfusion sequence is developed using a stack-of-stars design and tested at both stress and rest during free-breathing. A compressed sensing algorithm is used to compensate for the high undersampling rates, including a modified form with temporal pixel reordering designed to better cope with respiratory motion. Reconstructions were successful, despite large respiratory motion, in all cases. An example of a perfusion defect in a coronary artery disease patient is presented, with confirmation from recent SPECT myocardial perfusion scintigraphy.

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