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Abstract #0541

Inducibility of ventricular arrhythmia correlates with the indices of myocardial viability using manganese enhanced MRI (MEMRI) in a porcine ischemia reperfusion model

Atsushi Tachibana1,2,3, Junaid Zaman1, Yuko Tada1, Michelle R. Santoso1, and Phillip C. Yang1

1Cardiovascular Medicine, Stanford University, Stanford, CA, United States, 2Radiology, AIC Yaesu Clinic, Tokyo, Japan, 3Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan

Peri-infarct region (PIR), containing the viable but injured myocardium, has been related to the occurrence of ventricular arrhythmia. Reliable in vivo detection of arrhythmogenic region presents significant challenge. While delayed enhanced MRI (DEMRI) with gadolinium (Gd) detects the myocardial infarction, the non-specific property does not detect the viable but injured cardiomyocytes in the PIR. Manganese (Mn) enters the live cells via L-type calcium channel, and enables dual enhancement technique to identify the overlapping viable region in PIR. We measured the correlation between the volume of the PIR and inducibility of ventricular arrhythmia using porcine ischemia reperfusion model.

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