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Abstract #0542

In Vivo Hyperpolarized MRS Study Showing Improved Cardiac Metabolism in Type 1 Diabetes with Daily L-Carnitine Treatment.

Dragana Savic1, Kerstin N. Timm, Vicky Ball, Lisa Heather, and Damian J. Tyler

1University of Oxford, Oxford, United Kingdom

Carnitine acts as a buffer of acetyl-CoA units in the mitochondria, as well as facilitating transport of fatty acids, and carnitine levels are decreased in the diabetic heart. The purpose of this study was to investigate the effect of L-Carnitine supplementation on cardiac function and metabolism in the diabetic rat heart. We show that daily injections of L-Carnitine can alter cardiac metabolism in the in vivo diabetic rat heart, and can increase flux through pyruvate dehydrogenase. Such studies will allow a better understanding of the interactions between metabolism and function in the diabetic heart and may provide new insight into novel therapeutics.

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