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Abstract #0549

Cardiac fMRI - A Novel Approach for Reliably Detecting Myocardial Oxygenation Changes with Precise Modulation of Arterial CO2

Hsin-Jung yang1, Ilkay Oksuz2, Michael Klein3, Olivia Sobczyk3, Damini Dey1, Jane Sykes4, John Butler4, Xiaoming Bi5, Behzad Sharif1, Ivan Cokic1, Debiao Li1, Piotr Slomka1, Frank S Prato4, Joseph Fisher3, Sotirios Tsaftaris2, and Rohan Dharmakumar1

1Cedars Sinai Medical Center, Los Angeles, CA, United States, 2IMT School for Advanced Studies Lucca, 3University of Toronto, 4Lawson Health Research Institute, 5Siemens Healthcare

Although cardiac BOLD MRI can detect ischemic heart disease without ionizing radiation and contrast agents, its reliability remains poor due to the low sensitivity and specificity. We propose a novel strategy to overcome these barriers through: (i) an improved MRI strategy with free gas-exchange capability; (ii) repeat stimulation of heart using a validated prospective arterial CO2 targeting technique; and (iii) a statistical framework to increase the confidence measure of BOLD signal changes. Our results show that the proposed approach can be used to significantly increase the confidence in detecting myocardial BOLD response in conditions of health and disease.

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