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Abstract #0550

High-fat diet feeding in mice may partially protect the heart from pressure overload induced heart failure - a longitudinal study of cardiac metabolism and function

Emmy Manders1, Desiree Abdurrachim1, Miranda Nabben2, Klaas Nicolay1, and Jeanine J Prompers1,3

1Department of Biomedical Engineering, Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2Department of Genetics and Cell Biology, CARIM school for cardiovascular diseases, Maastricht University, Netherlands, 3Department of Radiology, University Medical Center, Utrecht, Netherlands

Obesity increases the risk of heart failure, but obese heart failure patients have a better prognosis and survival. Altered cardiac energy metabolism is proposed to be an important contributor to this discrepancy. With an in vivo longitudinal approach measuring cardiac function (MRI), energetics (31P-MRS) and lipid content (1H-MRS) during the development of heart failure we have shown that cardiac function was less impaired in obese mice compared with lean mice after induction of pressure overload. This suggests that metabolic adaptations in obese mice are not detrimental and may even be beneficial in heart failure development.

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