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Abstract #0556

Hyperpolarized 13C MRS of the Human Heart

Albert P. Chen1, Justin Y.C. Lau2,3, Benjamin J. Geraghty2,3, William J. Perks4, Idan Roifman5, Graham A. Wright2,3,5, Kim A. Connelly6, and Charles H. Cunningham2,3

1GE Healthcare, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Medical Biophysics, University of Toronto, Toronto, ON, Canada, 4Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Cardiology, St. Michael’s Hospital, Toronto, ON, Canada

The feasibility of acquiring hyperpolarized 13C images from human hearts following injections of HP [1-13C]pyruvate solution has been recently demonstrated. Following the rapid multi-slice 13C imaging acquisition, 13C spectroscopic data were acquired from the whole heart to detect any residual hyperpolarized magnetization. 13C pyruvate, lactate, alanine and bicarbonate were observed in all 5 subjects. 13CO2 was also detected in two of the datasets. Good inter-subject consistency in the observed metabolite ratios from these spectra demonstrated the potential for changes in cardiac metabolism due to disease to be interrogated with simple whole-heart spectroscopy.

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