Abstract #0556

Hyperpolarized 13C MRS of the Human Heart

Albert P. Chen¹, Justin Y.C. Lau^2,3, Benjamin J. Geraghty^2,3, William J. Perks⁴, Idan Roifman⁵, Graham A. Wright^2,3,5, Kim A. Connelly⁶, and Charles H. Cunningham^2,3

¹GE Healthcare, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Cardiology, St. Michael’s Hospital, Toronto, ON, Canada

The feasibility of acquiring hyperpolarized ¹³C images from human hearts following injections of HP [1-¹³C]pyruvate solution has been recently demonstrated. Following the rapid multi-slice ¹³C imaging acquisition, ¹³C spectroscopic data were acquired from the whole heart to detect any residual hyperpolarized magnetization. ¹³C pyruvate, lactate, alanine and bicarbonate were observed in all 5 subjects. ¹³CO₂ was also detected in two of the datasets. Good inter-subject consistency in the observed metabolite ratios from these spectra demonstrated the potential for changes in cardiac metabolism due to disease to be interrogated with simple whole-heart spectroscopy.

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