Abstract #0557

In vivo metabolic imaging of neuroinflammation following traumatic brain injury using hyperpolarized [1-13C] pyruvate

Caroline Guglielmetti^1,2, Austin Chou^1,2, Karen Krukowski^1,2, Maria Serena Paladini^1,2, Lara-Kirstie Riparip^1,2, Susanna Rosi^1,2,3, and Myriam Chaumeil^2,4

¹Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, United States, ²Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, ³Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, ⁴Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

This study demonstrates that metabolic imaging of hyperpolarized [1-¹³C] pyruvate can detect increased hyperpolarized lactate production in vivo in a preclinical model of Traumatic Brain Injury. Correlative assays further demonstrate that this increased lactate is linked to the presence of pro-inflammatory macrophages that upregulate pyruvate dehydrogenase kinase 1, subsequently leading to regional pyruvate dehydrogenase inhibition. Metabolic imaging of hyperpolarized [1-¹³C] pyruvate thus has great potential to provide a novel tool for in vivo detection of neuroinflammation.

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