Meeting Banner
Abstract #0558

Toward Dynamic 3D Cardiac Perfusion Imaging Using bSSFP and Hyperpolarized tert-Butanol

Timothy Pagliaro1, Gopal Varma1, Li Zhao1, David C Alsop1, and Aaron K Grant1

1Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Perfusion imaging is a promising application for hyperpolarized tracers, as they provide high signal with no endogenous background. Hyperpolarized 13C labeled tert-butanol is a perfusion agent with long T1 and T2 relaxation times in vivo. Moreover, because it diffuses freely through tissue, bolus injections of tert-butanol are largely extracted from the vasculature on a first pass, and the residence time in tissue is on the order of tens of seconds. This provides a long time frame for dynamic imaging. Here we demonstrate the feasibility of time-resolved 3D cardiac perfusion imaging in rats.

This abstract and the presentation materials are available to members only; a login is required.

Join Here