Abstract #0559

Detection of Bacteria-specific metabolism using hyperpolarized 13C pyruvate

Renuka Sriram¹, Jinny Sun¹, Javier Villanueva-Meyer¹, Justin DesLos Santos¹, Christopher Mutch¹, Oren Rosenberg², Mark Van Criekinge¹, John Kurhanewicz¹, David Wilson¹, and Michael Ohliger¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Infectious Diseases, University of California San Francisco, San Francisco, CA, United States

Bacterial infection is a major health problem, with high morbidity and mortality. Current imaging techniques have limited ability to differentiate infection from either tumor or sterile inflammation, and invasive tissue sampling is frequently required. There is currently no clinically-available non-invasive method to directly detect living bacteria in vivo. We describe a method for detecting bacteria specific metabolism using hyperpolarized ¹³C pyruvic acid.

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