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Abstract #0559

Detection of Bacteria-specific metabolism using hyperpolarized 13C pyruvate

Renuka Sriram1, Jinny Sun1, Javier Villanueva-Meyer1, Justin DesLos Santos1, Christopher Mutch1, Oren Rosenberg2, Mark Van Criekinge1, John Kurhanewicz1, David Wilson1, and Michael Ohliger1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Infectious Diseases, University of California San Francisco, San Francisco, CA, United States

Bacterial infection is a major health problem, with high morbidity and mortality. Current imaging techniques have limited ability to differentiate infection from either tumor or sterile inflammation, and invasive tissue sampling is frequently required. There is currently no clinically-available non-invasive method to directly detect living bacteria in vivo. We describe a method for detecting bacteria specific metabolism using hyperpolarized 13C pyruvic acid.

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