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Abstract #0560

In vivo pH imaging using hyperpolarized 13C-labelled zymonic acid

Stephan Duewel1,2,3, Christian Hundshammer1,2, Malte Gersch4, Benedikt Feuerecker1, Axel Haase3, Steffen J Glaser2, Markus Schwaiger1, and Franz Schilling1

1Department of Nuclear Medicine, Technical University of Munich, Munich, Germany, 2Department of Chemistry, Technical University of Munich, Garching, Germany, 3Institute of Medical Engineering, Technical University of Munich, Garching, Germany, 4Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

Pathologies which overrule natural pH regulatory mechanisms such as ischemia, inflammation or tumors can trigger local pH changes in the human body. Currently, clinical routine measurement of extracellular pH is limited to measuring systemic blood pH. We synthesized, characterized, calibrated and applied [1,5-13C2]zymonic acid (ZA) as a novel hyperpolarized 13C pH biosensor. With its demonstrated features both in vitro and in vivo (bladder, healthy kidney, Mat B III adenocarcinoma), we believe that ZA could help localize and quantify regions with aberrant acid-base balance, allowing for improved understanding, diagnostics and therapy of common diseases.

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