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Abstract #0593

Remodeling of resting state functional connectivity following thyromimetic induced remyelination in the mouse brain

Neele Saskia Hübner1, Annika Carolin Hammerschmitt1, Thiago Marques De Melo1,2, Thomas Bienert1, Jürgen Hennig1, Dominik von Elverfeldt1, and Laura Adela Harsan1,3,4

1Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany, 3Laboratory of Engineering, Informatics and Imaging, University of Strasbourg, Strasbourg, France, 4Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France

Characterization of the brain network architecture and its alterations in pathologies are essential for a better understanding of mechanisms of action in health and disease and paves the way for the development of targeted therapeutic strategies. In the field of demyelinating disorders, thyromimetic treatment provides a promising remyelinating strategy inducing oligodendrogenesis in vitro. We tested the potential of sobetirome (GC-1), a thyroid hormone analogue, to induce remyelination in vivo in the cuprizone demyelinated mouse model and we investigated its action on the resting state (rsfMRI) mouse brain functional connectivity.

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