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Abstract #0594

Genetic rescue of brain morphometry in a mouse model of neurodevelopmental disorder

Rylan Allemang-Grand1, Jacob Ellegood1, Leigh Spencer Noakes1, Brian J Nieman1, and Jason P Lerch1

1Neurosciences and Mental Health, SickKids Hospital, Toronto, ON, Canada

In this study, we scanned a mouse model of Rett syndrome before and after reactivation of Mecp2, the gene strongly implicated in the disorder. We found that reactivation of Mecp2 at three different time points in adulthood lead to drastic growth of the neuroanatomy across many regions of the cortex, cerebellum and medulla. Our findings demonstrate that the developmental delayed brain retains an innate plasticity that can be recruited to restore neuroanatomical structure in adulthood.

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