In this study, we scanned a mouse model of Rett syndrome before and after reactivation of Mecp2, the gene strongly implicated in the disorder. We found that reactivation of Mecp2 at three different time points in adulthood lead to drastic growth of the neuroanatomy across many regions of the cortex, cerebellum and medulla. Our findings demonstrate that the developmental delayed brain retains an innate plasticity that can be recruited to restore neuroanatomical structure in adulthood.
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