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Abstract #0604

MRI vs. X-ray scattering: comparative study of myelin distribution, fiber direction and white matter tracts in mouse brain

Marios Georgiadis1, Zirui Gao1, Dario Zingariello1, Valerio Zerbi2, Marianne Liebi3, Stefan Sommer1, Mark Augath1, Oliver Bunk3, Manuel Guizar-Sicairos3, Aileen Schroeter1, and Markus Rudin1

1Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland, 2Neural Control of Movement Lab, ETH Zurich, Zurich, Switzerland, 3Paul Scherrer Institute, Switzerland

MRI is the method of choice for brain imaging. However, it uses indirect structural information to infer densities of molecules such as myelin, and water diffusion direction as a proxy for fiber direction. Small-angle X-ray scattering tensor tomography (SAXSTT) provides an alternative approach to assess myelin distribution and fiber direction using directly structural information related to the molecular structure of myelin sheath. We applied SAXSTT to mouse brain to validate and compare different MRI methods (MT, DWI). We found a high degree of similarity with MT macromolecule distribution, and also DWI-derived white matter tracts, but with significant region-specific differences.

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