In this study, using 3D confocal microscopy to extract histological fiber orientation distributions, we validate tract-specific measures of dispersion and orientation derived from high angular resolution diffusion imaging techniques. We find a correlation between histological and diffusion measures of dispersion in q-ball imaging and constrained spherical deconvolution. We also find that an increased dispersion leads to greater error in fiber orientation estimates, as well as the presence of false positive peaks in the diffusion profiles. Future work will validate these measures in more high angular resolution diffusion techniques and microstructural models.
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