Abstract #0614

Subtypes Evaluation of Motor Dysfunction in Parkinson’s Disease using Neuromelanin-sensitive Magnetic Resonance Imaging

Tao Gong^1,2, Yuanyuan Xiang³, Guangbin Wang⁴, and Richard A.E. Edden²

¹MRI, Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Shandong University, Jinan, People's Republic of China, ⁴MRI, Shandong Medical Imaging Research Institute

The aim of this study was to evaluate the differences in NM-MRI between PD motor subtypes. We compared the signal intensity contrast ratios in medial and lateral regions of the SNc using NM-MRI in TD, PIGD and controls. The results demonstrated more severe signal attenuation in the medial part of SNc in PIGD patients compared with TD group. And the medial part of SNc showed high power to discriminate the PD motor subtypes. NM-MRI affords us a valuable examination method to discriminate the PD motor subtypes, providing a new evidence for the neuropathological basis of differences between the two subtypes.

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