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Abstract #0615

Reproducible detection of nigral iron deposition in Parkinson’s disease: Validation in two cohorts

Jason Langley1, Naying He1,2, Daniel E Huddleston3, Fuhua Yan2, and Xiaoping Hu4

1Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, 2Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, People's Republic of China, 3Department of Neurology, Emory University, Atlanta, GA, United States, 4Department of Bioengineering, University of California Riverside, Riverside, CA, United States

A characteristic of Parkinson's disease is neuronal loss in substantia nigra pars compacta (SNpc).In healthy subjects, SNpc contains a dense distribution of neuromelanin containing dopaminergic neurons and significant degeneration in SNpc has occurred at the time Parkinsonian symptom onset. Furthermore, extensive evidence suggests that iron deposition is related to neuronal loss and reduction of neuromelanin in SNpc. In this abstract, we examine the reproducibility of iron deposition in SNpc.

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