Abstract #0615

Reproducible detection of nigral iron deposition in Parkinson’s disease: Validation in two cohorts

Jason Langley¹, Naying He^1,2, Daniel E Huddleston³, Fuhua Yan², and Xiaoping Hu⁴

¹Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, ²Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, People's Republic of China, ³Department of Neurology, Emory University, Atlanta, GA, United States, ⁴Department of Bioengineering, University of California Riverside, Riverside, CA, United States

A characteristic of Parkinson's disease is neuronal loss in substantia nigra pars compacta (SNpc).In healthy subjects, SNpc contains a dense distribution of neuromelanin containing dopaminergic neurons and significant degeneration in SNpc has occurred at the time Parkinsonian symptom onset. Furthermore, extensive evidence suggests that iron deposition is related to neuronal loss and reduction of neuromelanin in SNpc. In this abstract, we examine the reproducibility of iron deposition in SNpc.

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