The results of recent diffusion tensor imaging (DTI) studies on amyotrophic lateral sclerosis (ALS) have been inconclusive and controversial. We performed a voxel-based meta-analysis to identify statistical consensus between published DTI studies for altered white matter (WM) microarchitecture in ALS. Our findings provides a thorough profile of WM microarchitecture alterations in ALS and further evidence that the neuronal degeneration is not limited to the corticospinal tract but also includes the extra-motor areas, supporting the view of ALS being a multisystem degenerative disorder involving WM.
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