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Abstract #0616

Altered white matter microarchitecture in amyotrophic lateral sclerosis:a voxel-based meta-analysis of diffusion tensor imaging

Guangxiang Chen1, Feifei Zhang1, Song Wang1, Xiaoqi Huang1, and Qiyong Gong1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, People's Republic of China

The results of recent diffusion tensor imaging (DTI) studies on amyotrophic lateral sclerosis (ALS) have been inconclusive and controversial. We performed a voxel-based meta-analysis to identify statistical consensus between published DTI studies for altered white matter (WM) microarchitecture in ALS. Our findings provides a thorough profile of WM microarchitecture alterations in ALS and further evidence that the neuronal degeneration is not limited to the corticospinal tract but also includes the extra-motor areas, supporting the view of ALS being a multisystem degenerative disorder involving WM.

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