Abstract #0617

Diffusion and T2 characterizations in hindbrain and spinal cord in SOD1 mouse model of ALS

Luke Xie¹, Robert Brendza², Maj Hedehus¹, Sara Dominguez², Oded Foreman³, Arundhati Sengupta Ghosh², William J. Meilandt², Gai Ayalon², and Richard A. D. Carano¹

¹Biomedical Imaging, Genentech, South San Francisco, CA, United States, ²Neuroscience, Genentech, South San Francisco, CA, United States, ³Pathology, Genentech, South San Francisco, CA, United States

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease characterized by motor neuron loss and eventual paralysis and respiratory failure. The SOD1 transgenic mouse model exhibits many aspects of human ALS and is useful for evaluating treatment strategies. MRI of the nervous system can provide the critical insights to motor neuron and upper body functional deterioration in ALS. In this study, we applied T₂ and DTI to assess gray and white matter degeneration in the brain and cervical spine in a SOD1 mouse model.

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