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Abstract #0620

Feasibility and evaluation of free-breathing and self-gated cartesian-sampled T1-weighted 4D MRI with compressed sensing resulting in combined diagnostic image quality and perfusion analysis

Christer Ruff1, Jakob Weiss1, Ahmed Othman1, Petros Martirosian2, Marcel Dominik Nickel3, Robert Grimm3, Manuel Kolb1, Matthias K√ľndel1, Fabian Bamberg1, Konstantin Nikolaou1, and Mike Notohamiprodjo1

1Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany, 2Section on Experimental Radiology, University Hospital Tuebingen, 3Siemens Healthcare, Erlangen, Germany

In clinical practice, a remaining challenge of dynamic contrast-enhanced (DCE)-MRI is to acquire a high spatio-temporal resolution without motion artifacts and diagnostic quality, despite acquisitions over several minutes. In particular, iterative reconstruction techniques have brought free-breathing acquisitions in clinical range. In this study, we proved feasibility and evaluated a prototype Cartesian-sampled fat-saturated T1-weighted 3D gradient-echo sequence with automated respiratory self-gating and compressed sensing reconstruction (VIBESG-CS) for continuous dynamic contrast-enhanced (DCE) MRI and perfusion analysis including lesion detection of the liver using a Tofts model. VIBESG-CS including perfusion analyisis showed better motion robustness and similar lesion conspicuity compared to a standard morphology sequence (fat-saturated T2-TSE).

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