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Abstract #0621

Robust arterial input functions by fitting the complex DCE-MRI signal: a test-retest study in prostate cancer

Edzo M.E. Klawer1, Petra J. van Houdt1, Frank F.J. Simonis2, Cornelis A.T. van den Berg2, Floris J. Pos1, Stijn W.T.P. Heijmink3, and Uulke A. van der Heide1

1Department of radiation oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands, 2Department of radiation oncology, Imaging Division, University Medical Center, Utrecht, Netherlands, 3Department of radiology, The Netherlands Cancer Institute, Amsterdam, Netherlands

The arterial input function is still one of the main problems for quantitative DCE analysis. In this study, we show that the repeatability of individual AIFs improve by using the complex signal instead of magnitude or phase signal alone by using test-retest DCE-MRI data of prostate cancer. This will eventually result in an accurate quantitative DCE-MRI analysis by including patient inter and intra-variability.

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