Abstract #0622

Evaluation of Approximation Method for B1+ Correction using Digital Reference Object in Prostate DCE-MRI

Xinran Zhong^1,2, Holden Wu^1,2, Krishna Nayak³, and Kyunghyun Sung^1,2

¹Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States

A digital reference object (DRO) for prostate dynamic contrast-enhanced MRI application is created by modifying DRO created by the RRSNA Quantitative Imaging Biomarkers Alliance (QIBA). Our previously proposed approximation B₁⁺ correction method for pharmacokinetic modeling was then tested on this DRO assuming B₁⁺variation of 20%, considering practical considerations such as fitting method, arterial input function selection and noise level. The proposed approximation method introduced error is shown to be negligible compared to B₁⁺ introduced error and noise introduced error.

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