Previous work has shown that hyperpolarized [1,4-13C2]fumarate is a probe of cellular necrosis. We demonstrate here that the ratio of cardiac hyperpolarized malate to fumarate is increased by a factor of $$$\sim$$$82 one day after cryoinduced myocardial infarction in rats, decreasing to an $$$\sim$$$30-fold increase one week after injury. We additionally image this injury with a novel spiral multiband pulse sequence. Hyperpolarized fumarate therefore forms a sensitive probe of myocardial injury in vivo, and could form a clinical monitor of cellular damage and necrosis after infarction.
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