Abstract #0637

Time Resolved In Vivo Myofiber Orientations from Combined Cardiac DENSE and cDTI

Patrick Magrath^1,2, Luigi E. Perotti ^1,2, Eric Aliotta ^2,3, Ilya A. Verzhbinsky ², Kévin Moulin², and Daniel B. Ennis^1,2,3

¹Department of Bioengineering, University of California, Los Angeles, CA, United States, ²Department of Radiological Sciences, University of California, Los Angeles, CA, United States, ³Biomedical Physics IDP, University of California, Los Angeles, CA, United States

Resolving the dynamics of cardiac myofiber orientations with cDTI could have significant value in the assessment of cardiac disease. Unfortunately, cDTI measurements are not reliable at all cardiac phases and would require extremely long acquisitions. Fusing cDTI with time-resolved displacement maps from cine DENSE could enable evaluation of the dynamics of myofiber orientations using cDTI obtained at a single cardiac phase. The objective of this study was to generate dynamic myocardial fiber maps and validate the approach with dual-phase cDTI measurements.

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