Skeletal muscle injury is often accompanied by fibrosis, fatty infiltration, and edema. There is great need for imaging readouts to detect and quantify such compositional changes, which would aid understanding and greatly assist in the development of emerging therapies. The goal of this work was to use a multi-modality approach, combining magnetic resonance elastography (MRE; muscle stiffness, fibrosis) with diffusion-weighted imaging (DWI; myocyte integrity) and T2-mapping (edema, inflammation) to provide a comprehensive assessment of muscle injury development and regeneration. The multi-modality assessment provided differential readouts of the deformation-induced muscle injury development and regeneration process.
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