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Abstract #0658

Correlation Time Mapping of Articular Cartilage: correlation with tissue composition and structure

Hassaan Elsayed1,2, Stefan Zbyn2, Mikko J Nissi3,4, Jari Rautiainen1,2,3,5, Matti Hanni1,2,5, and Miika T Nieminen1,2,5

1Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, 5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Correlation time ($$$\tau_c$$$) is a physical property of the tissue that describes the dynamics of water molecules in their microenvironment. In this study, $$$\tau_c$$$ and T2 maps were obtained from enzymatically digested bovine samples. To evaluate the relationship between $$$\tau_c$$$and macromolecular components of cartilage, depth-wise $$$\tau_c$$$ profiles were correlated with quantitative histological measurements. The same comparison was performed for T2 data. Our results suggest that $$$\tau_c$$$ is sensitive to the laminar architecture of cartilage and to the proteoglycan content in the radial zone. $$$\tau_c$$$ provides complementary information to conventional T2 mapping.

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