Abstract #0659

Correlation of 7T gagCEST MRI with Electromechanical and Biochemical Properties of Femoral Articular Cartilage

Sander Brinkhof¹, Razmara Nizak², Sotcheadt Sim³, Vitaliy Khlebnikov¹, Dennis Klomp¹, and Daniel Saris^2,4

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Orthopaedics, University Medical Center Utrecht, Utrecht, ³Biomomentum Inc., Laval, QC, Canada, ⁴MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Netherlands

The purpose of this study was to validate the 7T 3D gagCEST measurements obtained in patients in vivo, using correlation of MRI GAG values with electromechanical mapping of the articular cartilage and biochemical analyses. Five patients were scanned before their total knee replacement, after which the extracted cartilage samples were used for electromechanical mapping and biochemical analyses. GAG content as determined by gagCEST MRI shows to be significantly correlated with biochemically measured GAG dry weight and with electromechanical mapping. This work shows that the electromechanical properties of cartilage are correlated with gagCEST MRI values.

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