Complete assessment of blood flow to the brain requires both knowledge of blood flow through the large arteries and perfusion at the tissue level. However, separate acquisition of dynamic angiograms and perfusion maps is time-consuming. In this work a 4D implementation of the Combined Angiography and Perfusion using Radial Imaging and Arterial Spin Labeling (CAPRIA) sequence is presented, allowing the reconstruction of whole-brain dynamic angiograms and time-resolved perfusion maps from the same raw data set. In addition, a variable flip angle imaging scheme is shown to benefit the visualization of tissue perfusion without compromising angiographic image quality.
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