Meeting Banner
Abstract #0698

Segmentation of the Human Nucleus Accumbens Using High-Resolution Diffusion Tractography

Samuel Cartmell1, Qiyuan Tian, Grant Yang, Christoph Leuze, Jennifer McNab, and Casey Harrison Halpern

1Stanford University, Palo Alto, CA, United States

Tractography-based parcellation of the Nucleus Accumbens (NAc) was performed using high-resolution diffusion data from the Human Connectome Project. Analysis of clustering indicated the NAc was best separated into 2 subregions, consistent with anatomical and histological studies of animals. Output of the procedure gave qualitatively similar results across subjects, producing clusters that tended to occupy the ventromedial and dorsolateral portions of the NAc. The ventromedial subregion demonstrated increased task fMRI activation and displayed preferential connections to known biased projection areas such as medial orbitofrontal cortex. Finally, qualitatively similar results were obtained by performing the clustering procedure on a separate, lower-quality dataset.

This abstract and the presentation materials are available to members only; a login is required.

Join Here